van Mil Group

Publications:

Chatterjee S, Bijsmans IT, van Mil SW, Augustijns P, Annaert P, Toxicity and intracellular accumulation of bile acids in sandwich-cultured rat hepatocytes: Role of glycine conjugates. Toxical In Vitro. 2014 Mar;28(2):218-30. (link to paper)


van Schaik FD, Gadaleta RM, Schaap FG, van Mil SW, Siersema PD, Oldenburg B, van Erpecum KJ. Pharmacological activation of the bile acid nuclear farnesoid X receptor is feasible in patients with quiescent Crohn's colitis. PLoS One. 2012;7(11):e49706. doi: 10.1371/journal.pone.0049706. Epub 2012 Nov 26. PMID: 23189156 (link to paper)


van der Velden LM, Golynskiy MV, Bijsmans IT, van Mil SW, Klomp LW, Merkx M, van de Graaf SF. Monitoring bile acid transport in single living cells using a genetically encoded Förster resonance energy transfer sensor. Hepatology. 2013 Feb;57(2):740-52. doi: 10.1002/hep.26012. Epub 2013 Jan 8. PMID: 22899095 (link to paper)


Hollman DA, Milona A, van Erpecum KJ, van Mil SW. Anti-inflammatory and metabolic actions of FXR: Insights into molecular mechanisms. Biochim Biophys Acta. 2012 Nov;1821(11):1443-52. PMID:22820415 (link to paper)

Nijmeijer RM, Gadaleta RM, van Mil SWC, van Bodegraven AA, Crusius JBA, Dijkstra G, Hommes DW, de Jong DJ, Stokkers PCF, Verspaget HW, Weersma RK, van der Woude CJ, Stapelbroek JM, Schipper MEI, Wijmenga C, van Erpecum KJ, Oldenburg B. Farnesoid X Receptor (FXR) Activation and FXR Genetic Variation in Inflammatory Bowel Disease. PLoS ONE 2011 6(8): e23745. (link to paper)

Raffaella M. Gadaleta, Bas Oldenburg, Ellen C.L. Willemsen, Maureen Spit, Stefania Murzilli, Lorena Salvatore, Leo W.J. Klomp, Peter D. Siersema, Karel J. van Erpecum, Saskia W.C. van Mil. Activation of bile salt nuclear receptor FXR is repressed by pro-inflammatory cytokines activating NF-κB signalling. BBA MOLECULAR AND CELL BIOLOGY OF LIPIDS. 2011 Aug;1812(8):851-8. (link to paper)

Gadaleta RM, van Erpecum KJ, Oldenburg B, Spit M, Willemsen ECL, Murzilli S, Renooij W, Siersema PD, Penna G, Laverny G, Danese S, Adorini L, Moschetta A, van Mil SWC. Farnesoid X receptor represses inflammation and preserves the intestinal barrier improving DSS-induced colitis in mice. Gut. 2011 April; 60 (4): 463-472. (link to paper)

van der Woerd WL, van Mil SWC, Stapelbroek JM, Klomp LWJ, van de Graaf SFJ, Houwen RHJ. Familial cholestasis: progressive familial intrahepatic cholestasis, benign recurrent intrahepatic cholestasis and intrahepatic cholestasis of pregnancy. Best Pract Res Clin Gastroenterol. 2010 Oct;24(5):541-53. (link to paper)

Milona A, Owen B, Cobbold J, Cox J, Boudjelal M, Cairns W, Parker MG, White R, van Mil SWC #, and Williamson C#. Hepatic bile acids accumulate during pregnancy as a result of reduced Farnesoid-X-Receptor (FXR) function. # Both authors contributed equally. Hepatology. 2010 Oct;52(4):1341-9. (link to paper)

Gadaleta RM, van Mil SWC, Oldenburg B, Siersema PD Klomp LW, van Erpecum KJ. Bile acids and their nuclear receptor FXR: Relevance for hepatobiliary and gastrointestinal disease. Biochim Biophys Acta. 2010, 1801(7):683-92. (link to paper)

Milona A, Owen BM, van Mil SWC, Dormann D, Mataki C, Boudjelal M, Cairns W, Schoonjans K, Milligan S, Parker MG, White R, Williamson C. The Normal Mechanisms of Pregnancy-induced Liver Growth are Not Maintained in Mice Lacking the Bile Acid Sensor Fxr. Am J Physiol Gastrointest Liver Physiol. 2010 Feb;298(2):G151-8. (link to paper)

Owen BM, Milona A, van Mil SWC, Clements P, Holder J, Boudjelal M, Cairns W, Parker MG, White R, Williamson C. Hepatoprotection Against Lithocholic Acid Involving Adaptive Activation of the Pregnane-X-Receptor (PXR). Drug Metab Dispos. 2010 Jan;38(1):143-9. (link to paper)

Dixon PH, van Mil SWC, Chambers J, Strautnieks S, Thompson R, Lammert F, Kubitz R, Keitel V, Glantz A, Mattsson LA, Marschall HU, Molokhia M, Moore G, Linton K, Williamson C. Contribution of variant alleles of ABCB11 to susceptibility to intrahepatic cholestasis of pregnancy. Gut, 2009 58(4):537-44. (link to paper)

Owen BM, Van Mil SWC, Boudjelal M, McLay I, Cairns W, Elias E, White R, Williamson C, Dixon PH. Sequencing and functional assessment of hPXR (NR1I2) variants in intrahepatic cholestasis of pregnancy. Xenobiotica, 2008, 38(10):1289-97. (link to paper)

van Mil SWC, Milona A, Dixon PH, Mullenbach R, Geenes VL, Chambers J, Shevchuk V, Moore GE, Lammert F, Glantz AG, Mattsson LA, Whittaker J, Parker MG, White R, Williamson C. Functional variants of the central bile acid sensor FXR identified in intrahepatic cholestasis of pregnancy. Gastroenterology, 2007;133(2):507-16 (link to paper)

van Mil SWC, Houwen RHJ, Klomp LWJ. Genetics of familial intrahepatic cholestasis syndromes. Journal of Medical Genetics, 2005, 42(6) 449-63. (link to paper)

van Mil SWC, van der Woerd W, van der Brugge G, Sturm E, Jansen PL, Bull L, van den Berg IET, Berger R, Houwen RHJ, Klomp LWJ. Benign recurrent intrahepatic cholestasis type 2 is caused by mutations in ABCB11. Gastroenterology, 2004, 127 (2) 379-384. (link to paper)

van Mil SWC, van Oort MM, van den Berg IET, Berger R, Houwen RHJ, Klomp LWJ. FIC1 is expressed at apical membranes of different epithelial cells in the digestive tract and is induced in the small intestine during postnatal development of mice. Pediatric Research 2004, 56 (6) 981-987. (link to paper)

Klomp LWJ, Vargas J, van Mil SWC, Pawlikowska SWC, Strautnieks SS, van Eijk MJT, Juijn JA, Pabón-Peña C, Smith L, Deyoung J, Byrne JA, Gombert J, van der Brugge G, Berger R, Jankowska I, Pawlowska J, Villa E, Knisely AS, Thompson RJ, Freimer NB, Houwen RHJ and Bull LN. Characterization of mutations in atp8b1 associated with hereditary cholestasis. Hepatology, 2004, 40 (1) 27-38. (link to paper)

Lykavieris P, van Mil SWC, Cresteil D, Fabre M, Hadchouel M, Klomp LWJ, Bernard O, Jacquemin E. Progressive familial intrahepatic cholestasis type 1 and extrahepatic features: no catch-up of stature growth, exacerbation of diarrhea, and appearance of liver steatosis after liver transplantation. Journal of Hepatology 2003, (39) 447-452. (link to paper)

van Mil SWC, Klomp LWJ, Bull LN, Houwen RHJ. FIC1 disease; a spectrum of intrahepatic cholestatic disorders. Seminars in liver disease 2001; 21 (4), 535-544. (link to paper)

Eppens E*, van Mil SWC*, de Vree M, Mok K, Juijn JA, Oude Elferink R, Berger R, Houwen RHJ, Klomp LWJ. FIC1, the protein affected in two forms of hereditary cholestasis, is localized in the cholangiocyte and the canalicular membrane of the hepatocyte. *Both authors contributed equally. Journal of Hepatology 2001; 35, 436-443. (link to paper)