Lens Group

Selected papers Lens group:

Hadders MA, Lens SM. Cell biology. Mind the midzone. Science 345:265 (2014). Comment.

Van der Horst A, Lens SM. Cell division: control of the chromosomal passenger complex in time and space. Chromosoma 123:25 (2014)

van der Waal MS, Saurin AT, Vromans MJ, Vleugel M, Wurzenberger C, Gerlich DW, Medema RH, Kops GJ, Lens SM. Mps1 promotes rapid centromere accumulation of Aurora B. EMBO Rep 13: 847 (2012)

van der Waal MS, Hengeveld, RC, van der Horst A, Lens SM. Cell division control by the Chromosomal Passenger Complex. Exp Cell Res 318:1407 (2012)

Hengeveld RC, Hertz NT, Vromans MJ, Zhang C, Burlingame AL, Shokat KM, Lens SM. Development of a chemical genetic approach for human Aurora B kinase identifies novel substrates of the chromosomal passenger complex. Mol Cell Proteomics (2012)

Wang F, Ulyanova NP, van der Waal MS, Patnaik D, Lens SM, Higgins JM. A positive feedback loop involving Haspin and Aurora B promotes CPC accumulation at centromeres in mitosis. Curr Biol. 21:1061 (2011)

Saurin AT, van der Waal MS, Medema RH, Lens SM, Kops GJ. Aurora B potentiates Mps1 activation to ensure rapid checkpoint establishment at the onset of mitosis. Nat Commun. 2:316 (2011)

Avo Santos M, van de Werken C, de Vries M, Jahr H, Vromans MJ, Laven JS, Fauser BC, Kops GJ, Lens SM, Baart EB. A role for Aurora C in the chromosomal passenger complex during human preimplantation embryo development. Hum Reprod.26: 1868 (2011)

DeLuca KF, Lens SM, Deluca JG. Temporal changes in Hec1 phosphorylation control kinetochore-microtubule attachment stability during mitosis. J Cell Sci 124:622 (2011)

Lens SM, Voest EE, Medema RH. Shared and separate functions of polo-like kinases and aurora kinases in cancer. Nat Rev Cancer 10:825 (2010)

Vader G, Lens SM. Chromosome segregation: taking the passenger seat. Curr Biol. 20:R879 (2010)

van der Waal MS, Lens SM. Aurora B levels at the centromere key to its controversial role in the mitotic checkpoint? Cell Cycle 9:1456 (2010)

Maia AF, Feijão T, Vromans MJ, Sunkel CE, Lens SM. Aurora B kinase cooperates with CENP-E to promote timely anaphase onset. Chromosoma. 119:405 (2010)

Liu D, Vader G, Vromans MJ, Lampson MA, Lens SM. Sensing chromosome bi-orientation by spatial separation of Aurora B kinase from kinetochore substrates. Science 323:1350 (2009)

Vader G, Lens SM. The Aurora kinase family in cell division and cancer. Biochim. Biophys Acta 1786:60 (2008)

Vader G, Maia AF and Lens SM. The chromosomal passenger complex and the spindle assembly checkpoint: kinetochore-microtubule error correction and beyond. Cell Div. 3:10 (2008).

Jelluma N, Brenkman AB, van den Broek NJ, Cruijsen CW, van Osch MH, Lens SM, Medema RH, Kops GJ. Mps1 phosporylates Borealin to control Aurora B activity and chromosome alignment. Cell 132:233 (2008).

Vader G, Cruijsen CW, van Harn T, Vromans MJ, Medema RH, Lens SM. The Chromosomal Passenger Complex Controls Spindle Checkpoint Function Independent from Its Role in Correcting Microtubule Kinetochore Interactions. Mol Biol Cell 18:4553 (2007).

Wheatley SP, Barrett RM, Andrew PD, Medema RH, Morley SJ, Swedlow JR, Lens SM. Phosphorylation by aurora-B negatively regulates survivin function during mitosis. Cell Cycle 6:1220-1230 (2007).

Lens SM, Vader G, Medema RH. The case for Survivin as mitotic regulator. Curr Opin Cell Biol 18:616-622 (2006).

Lens SM, Rodriguez JA, Vader G, Span SW, Giaccone G, Medema RH. Uncoupling the Central Spindle-associated Function of the Chromosomal Passenger Complex from Its Role at Centromeres. Mol Biol Cell 17:1897-1909 (2006).

Rodriguez JA, Lens SM, Span SW, Vader G, Medema RH, Kruyt FA, Giaccone G. Subcellular localization and nucleocytoplasmic transport of the chromosomal passenger proteins before nuclear envelope breakdown. Oncogene 25:4867-4879 (2006).

Vader G, Medema RH, Lens SM. The chromosomal passenger complex: guiding Aurora-B through mitosis. J Cell Biol 173:833-837 (2006).

Vader G, Kauw JJ, Medema RH, Lens SM. Survivin mediates targeting of the chromosomal passenger complex to the centromere and midbody. EMBO Rep 7:85-92 (2006).

Lens SM, Medema RH. The survivin/Aurora B complex: its role in coordinating tension and attachment. Cell Cycle 2:507-510 (2003).

Lens SM, Wolthuis RM, Klompmaker R, Kauw J, Agami R, Brummelkamp T, Kops G, Medema RH. Survivin is required for a sustained spindle checkpoint arrest in response to lack of tension. EMBO J 22:2934-2947 (2003).