Kops Lab: Chromosome Segregation
Geert Kops (about the PI)
+31(0)88 75 55163 g.j.p.l.kops-at-umcutrecht.nl
Embryonic development and tissue homeostasis rely on error-free chromosome segregation during cell divisions. Chromosome segregation errors lead to aneuploidy, one of the most common genetic alterations found in human tumors, and strongly associated with poor clinical outcome.
Chromosome segregation is a highly dynamic process, strictly controlled by complex signaling networks. Our lab aims to understand the fundamental networks that ensure error-free chromosome segregation. These include the mitotic checkpoint, a surveillance mechanism that halts cell division until all chromosomes have established attachments to spindle microtubules, as well as the networks that build the kinetochore and that establish stable kinetochore-microtubule interactions. We furthermore wish to understand if errors in these networks are a cause of aneuploidy in tumors, how aneuploidy contributes to the tumor phenotype and whether we can target these networks to specifically kill tumor cells.
Questions we'd like answers to:
- How, when and where is the mitotic checkpoint activated and silenced, and how does it control the cell cycle machinery?
- How, when and where are kinetochore-microtubule interactions regulated
- Do defects in these processes underlie aneuploidy in development and cancer?
- Will targeting these processes provide opportunities for new anti-cancer therapies?
Approaches We use chemical genetics, quantitative proteomics, somatic cell gene targeting, high-resolution deconvolution imaging, biochemistry, cellular structure-function analyses, and animal aneuploidy models. We have additional collaborations with biophysicists, evolutionary genomics researchers, and cancer biologists.
SPYING ON CANCER (KIJKEN NAAR KANKER)
English SPYING ON CANCER is a short journey through the world of cancer research in The Netherlands. Inge Diepman and three investigators of the UMC Utrecht, the NKI-AvL and the Hubrecht Institute show how cancer cells originate and how with the help of advanced technologies the origins and spreading of cancer through the body can be studied. Produced by Roul Meijer.
Dutch KIJKEN NAAR KANKER is een korte reis door de wereld van het kankeronderzoek in Nederland. Inge Diepman en drie kankeronderzoekers van het UMC Utrecht, het NKI-AvL en het Hubrecht Instituut laten zien hoe kankercellen ontstaan en hoe met geavanceerde technologien het onstaan en uitzaaiing van kanker kan worden bestudeerd. Geproduceerd door Roul Meijer.