Adipocyte differentiation and function
PI: Eric Kalkhoven (about the group leader)
The aim of our group is to determine the molecular mechanisms behind adipocyte (dys)function in obesity, insulin resistance and lipodystrophy. We focus on adipocyte differentiation, the endocrine and metabolic functions of these cells and their communication with immune cells. Using state-of-the-art molecular biology and cell biology approaches, genetics, and recently also animal models, we have implicated iNKT cells in metabolism and unravelled a novel USP7-Tip60 pathway in adipogenesis in recent years.
In addition, we investigate the beneficial effects of exercise, with special emphasis on communication between muscle and liver.