de Rooij Group

Mechanical control of the endothelial barrier.
Oldenburg J, de Rooij J.
Cell Tissue Res. 2014 Mar;355(3):545-55. (link)

Cadherin mechanotransduction in tissue remodeling.
Twiss F, de Rooij J.
Cell Mol Life Sci. 2013 Nov;70(21):4101-16. (link)

HGF signaling regulates Claudin-3 dynamics through its C-terminal tyrosine residues.
Twiss F, Oldenkamp M, Hiemstra A, Zhou H, Matheron L, Mohammed S, de Rooij J.
Tissue Barriers. 2013 Oct 1;1(4):e27425. (link)

Mechanotransduction: vinculin provides stability when tension rises.
Spanjaard E, de Rooij J.
Curr Biol. 2013 Feb 18;23(4):R159-61. (link)

Mechanosensitive systems at the cadherin-F-actin interface.
Huveneers S, de Rooij J.
J Cell Sci. 2013 Jan 15;126(Pt 2):403-13. (link)

Vinculin-dependent Cadherin mechanosensing regulates efficient epithelial barrier formation.
Twiss F, Le Duc Q, Van Der Horst S, Tabdili H, Van Der Krogt G, Wang N, Rehmann H, Huveneers S, Leckband DE, De Rooij J.
Biol Open. 2012 Nov 15;1(11):1128-40. (link)

Quantitative imaging of epithelial cell scattering identifies specific inhibitors of cell motility and cell-cell dissociation.
Loerke D, le Duc Q, Blonk I, Kerstens A, Spanjaard E, Machacek M, Danuser G, de Rooij J.
Sci Signal. 2012 Jul 3;5(231):rs5. (link)

Vinculin associates with endothelial VE-cadherin junctions to control force-dependent remodeling.
Huveneers S, Oldenburg J, Spanjaard E, van der Krogt G, Grigoriev I, Akhmanova A, Rehmann H, de Rooij J.
J Cell Biol. 2012 Mar 5;196(5):641-52. (link)

Rap1 can bypass the FAK-Src-Paxillin cascade to induce cell spreading and focal adhesion formation.
Ross SH, Spanjaard E, Post A, Vliem MJ, Kristyanto H, Bos JL, de Rooij J.
PLoS One. 2012;7(11):e50072. (link)

Mechanotransduction at cadherin-mediated adhesions.
Leckband DE, le Duc Q, Wang N, de Rooij J.
Curr Opin Cell Biol. 2011 Oct;23(5):523-30. (link)

Vinculin potentiates E-cadherin mechanosensing and is recruited to actin-anchored sites within adherens junctions in a myosin II-dependent manner.
Le Duc Q, Shi Q, Blonk I, Sonnenberg A, Wang N, Leckband D, de Rooij J.
J Cell Biol. 2010 Jun 28;189(7):1107-15. (link)

cAMP-induced Epac-Rap activation inhibits epithelial cell migration by modulating focal adhesion and leading edge dynamics.
Lyle KS, Raaijmakers JH, Bruinsma W, Bos JL, de Rooij J.
Cell Signal. 2008 Jun; 20 ( 6 ): 1104-16 .

Integrin-dependent acto-myosin contraction regulates epithelial cell scattering.
De Rooij J, Kerstens A, Danuser G, Schwartz MA, Waterman-Storer CM.
J Cell Biol. 2005 Oct 10;171(1):153-64.

Structure and regulation of the cAMP-binding domains of Epac2.
Rehmann H, Prakash B, Wolf E, Rueppel A, De Rooij J, Bos JL, Wittinghofer A.
Nat Struct Biol 2003 Jan;10(1):26-32.

A novel Epac-specific cAMP analogue demonstrates independent regulation of Rap1 and ERK.
Enserink, JM*, Christensen AE*, De Rooij J*, Van Triest MH, SchwedeF, Genieser HG, Døskeland SO, Blank JL, Bos JL.
Nat Cell Biol 2002 Nov;4(11):901-6.

Rap1 signalling: adhering to new models.
Bos JL, de Rooij J, Reedquist KA.
Nat Rev Mol Cell Biol. 2001 May; 2 ( 5 ): 369-77.

Mechanism of regulation of the Epac family of cAMP-dependent RapGEFs.
de Rooij J, Rehmann H, van Triest M, Cool RH, Wittinghofer A, Bos JL.
J Biol Chem. 2000 Jul 7;275(27):20829-36.

Guanine Nucleotide Exchange Factor Specific for Rap1 and Rap2.
de Rooij, J., Boenink, N. M., van Triest, M., Cool, R. H., Wittinghofer, A., and Bos, J. L. PDZ-GEF1, a J Biol Chem. 1999 Dec 31; 274 ( 53 ): 38125-30 .

Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP.
de Rooij, J.*, Zwartkruis, F. J.*, Verheijen, M. H., Cool, R. H., Nijman, S. M., Wittinghofer, A., and Bos, J. L.
Nature. 1998 Dec 3; 396 ( 6710 ): 474-7.

Minimal Ras-binding domain of Raf1 can be used as an activation- specific probe for Ras.
de Rooij, J., and Bos, J. L.
Oncogene. 1997 Feb 6;14(5):623-5.