Burgering Group

Curriculum Vitae

Boudewijn M.Th. Burgering is working since 2003 as professor in Signal Transduction and since 2011 is Head Research at the Department Metabolic Diseases by the Division Biomedical Genetics of the University Medical Center Utrecht, the Netherlands and Collaborative Science Chair, Institute for Stem Cell Biology and Regenerative Medicine (inStem), Bangalore, India. He studied Molecular Sciences at the University of Wageningen and he received his PhD from the University of Leiden, where he studied the role of the small GTPase-p21ras in the signaling of growth factors and hormones. Amongst others this resulted in the identification of p21ras as a component of the insulin signalling pathway.

As a post-doctoral fellow he continued working on p21ras and insulin signalling in Utrecht at the Department of Physiological Chemistry. In 1995 a collaboration with Paul Coffer resulted in the discovery of the serine-threonine kinase PKB as a new target of insulin signalling.

Subsequently, his and other labs discovered  the O-box family of Forkhead-transcription-factors (FOXO) as important substrates of PKB. Since then the role of PKB/FOXO in cell signalling has been the central theme in his research. At present the paradigm is evolving that signalling through PKB/FOXO plays an important role in the aging process and that the incomplete functioning of this signaling provides an important contribution to the onset of age-related diseases such as cancer and diabetes.